Non-viral Gene Transfer Agents
Non-viral gene transfer agents offer several potential advantages over
recombinant viruses. They are non-infectious, relatively
non-immunogenic, have low acute toxicity, can accommodate a large DNA
plasmid and maybe produced simply on a large scale. They are limited by
their lower gene transfer efficiency than viruses and transient gene
expression. Numerous non-viral gene transfer systems have been proposed
including naked DNA, cationic liposomes and polymers.
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