Consortium Publications
Griesenbach U, Alton EW; on behalf of the UK Cystic Fibrosis Gene Therapy Consortium. Gene transfer to the lung: Lessons learned from more than 2 decades of CF gene therapy. Adv Drug Deliv Rev. 2008 Dec 24. [Epub ahead of print]. View Abstract
Griesenbach U, Smith SN, Farley R, Singh C, Alton EW. Validation of nasal potential difference measurements in gut-corrected CF knockout mice. Am J Respir Cell Mol Biol. 2008 Oct;39(4):490-6. Epub 2008 May 5. View Abstract
MacGregor G, Gray RD, Hilliard TN, Imrie M, Boyd AC, Alton EW, Bush A, Davies JC, Innes JA, Porteous DJ, Greening AP. Biomarkers for cystic fibrosis lung disease: application of SELDI-TOF mass spectrometry to BAL fluid. J Cyst Fibros. 2008 Sep;7(5):352-8. Epub 2008 Feb 1. View Abstract
Gray RD, MacGregor G, Noble D, Imrie M, Dewar M, Boyd AC, Innes JA, Porteous DJ, Greening AP. Sputum proteomics in inflammatory and suppurative respiratory diseases. Am J Respir Crit Care Med. 2008 Sep 1;178(5):444-52. Epub 2008 Jun 19. View Abstract
Hyde SC, Gill DR. Ignoring the nonsense: a phase II trial in cystic fibrosis. Lancet. 2008 Aug 30;372(9640):691-2. Epub 2008 Aug 20. View Detail
Unciti-Broceta A, Holder E, Jones LJ, Stevenson B, Turner AR, Porteous DJ, Boyd AC, Bradley M. Tripod-like cationic lipids as novel gene carriers. J Med Chem. 2008 Jul 24;51(14):4076-84. Epub 2008 Jun 26. View Abstract
Hilliard TN, Zhu J, Farley R, Escudero-Garcia S, Wainwright BJ, Jeffery PK, Griesenbach U, Bush A, Davies JC, Alton EW. Nasal abnormalities in cystic fibrosis mice independent of infection and inflammation. Am J Respir Cell Mol Biol. 2008 Jul;39(1):19-25. Epub 2008 Jan 31. View Abstract
Davies LA, McLachlan G, Sumner-Jones
SG, Ferguson D, Baker A, Tennant P, Gordon C, Vrettou C, Baker E, Zhu J, Alton
EW, Collie DD, Porteous DJ, Hyde SC, Gill DR. Enhanced lung gene expression
after aerosol delivery of concentrated pDNA/PEI complexes.
Mol Ther. 2008 Jul;16(7):1283-90. Epub
2008 May 20.
View Abstract
Davies LA, Varathalingam A, Painter H,
Lawton AE, Sumner-Jones SG, Nunez-Alonso GA, Chan M, Munkonge F, Alton EW, Hyde
SC, Gill DR. Adenovirus-mediated in utero expression of CFTR does not improve
survival of CFTR knockout mice.
Mol Ther. 2008 May;16(5):812-8. Epub
2008 Mar 11.
View Abstract
Griesenbach U, Meng C, Farley R, Cheng SH, Scheule RK, Davies MH, Wolstenholme-Hogg PC, ten Hove W, van der Hoeven P, Sinn PL, McCray PB Jr, Inoue M, Geddes DM, Hasegawa M, Frankel G, Wiles S, Alton EW. In vivo imaging of gene transfer to the respiratory tract. Biomaterials. 2008 Apr;29(10):1533-40. View Abstract
Regamey N, Ochs M, Hilliard TN, Mühlfeld C, Cornish N, Fleming L, Saglani S, Alton EW, Bush A, Jeffery PK, Davies JC. Increased airway smooth muscle mass in children with asthma, cystic fibrosis, and non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med. 2008 Apr 15;177(8):837-43. Epub 2008 Jan 24. View Abstract
Davies LA, Varathalingam A, Painter H, Lawton AE, Sumner-Jones SG, Nunez-Alonso GA, Chan M, Munkonge F, Alton EW, Hyde SC, Gill DR. Adenovirus-mediated In Utero Expression of CFTR Does Not Improve Survival of CFTR Knockout Mice. Mol Ther. 2008 Mar 11; [Epub ahead of print]. View Abstract
Larsen MD, Griesenbach U, Goussard S, Gruenert DC, Geddes DM, Scheule RK, Cheng SH, Courvalin P, Grillot-Courvalin C, Alton EW. Bactofection of lung epithelial cells in vitro and in vivo using a genetically modified Escherichia coli. Gene Ther. 2008 Mar;15(6):434-42. View Abstract
Rakonczay Z Jr, Hegyi P, Hasegawa M, Inoue M, You J, Iida A, Ignáth I, Alton EW, Griesenbach U, Ovári G, Vág J, Da Paula AC, Crawford RM, Varga G, Amaral MD, Mehta A, Lonovics J, Argent BE, Gray MA. CFTR gene transfer to human cystic fibrosis pancreatic duct cells using a Sendai virus vector. J Cell Physiol. 2008 Feb;214(2):442-55. View Abstract
Davies JC, Cunningham S, Alton EW, Innes JA. Lung clearance index in CF: a sensitive marker of lung disease severity. Thorax. 2008 Feb;63(2):96-7. View Details
Horsley AR, Gustafsson PM, Macleod KA, Saunders C, Greening AP, Porteous DJ, Davies JC, Cunningham S, Alton EW, Innes JA. Lung clearance index is a sensitive, repeatable and practical measure of airways disease in adults with cystic fibrosis. Thorax. 2008 Feb;63(2):135-40. View Abstract
Macgregor G, Gray RD, Hilliard TN, Imrie M, Boyd AC, Alton EW, Bush A, Davies JC, Innes JA, Porteous DJ, Greening AP. Biomarkers for cystic fibrosis lung disease: Application of SELDI-TOF mass spectrometry to BAL fluid. J Cyst Fibros. 2008 Jan 31; [Epub ahead of print]. View Abstract
Regamey N, Hilliard TN, Saglani S, Zhu J, Balfour-Lynn IM, Rosenthal M, Jeffery PK, Alton EW, Bush A, Davies JC. Endobronchial biopsy in childhood. Chest. 2008 Jan;133(1):312; author reply 313. View Detail
Griesenbach U, Munkonge FM, Sumner-Jones S, Holder E, Smith SN, Boyd AC, Gill DR, Hyde SC, Porteous D, Alton EW; UK Cystic Fibrosis Gene Therapy Consortium. Assessment of CFTR function after gene transfer in vitro and in vivo. Methods Mol Biol. 2008;433:229-42. View Abstract