2001
The Consortium is formed on the initiative of the Cystic Fibrosis Trust.
2002-2003
Reorganisation of the three groups and creation of specific working groups and core facilities at each of the three sites.
2004
Development of the first CpG-Free plasmids.
Start of the product evaluation study to assess the effectiveness of multiple gene transfer agents (GTAs) in pre-clinical studies.
2005
End of product evaluation. GL67A selected as gene transfer agents (GTAs) for clinical studies.
2006
Tracking Study commences.
Creation of a modular clinical plasmid design (after extensive plasmid development).
hCEFI promoter established as having superior duration of expression in pre-clinical models (after multiple promoter elements are tested).
The clinical trial plasmid pGM169 produced in Oxford.
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2007
Completion of the Tracking Study.
Commercial manufacturing of GL67A and pGM169 begins.
Testing and selection of clinical nebulisers.
Extensive clinical assay development ahead of clinical studies.
Design of a mixing device for correct mixing of GL67A and pGM169.
2008
Run-in Study commences.
2009
Single Dose Clinical Trial (Pilot study) commences.
2010
Extensive pre-clinical multi-dose toxicology studies commence (these are required by law ahead of multi-dose studies in CF patients).
2011
Completion of Single Dose Clinical Trial (Pilot study).
Extensive pre-clinical multi-dose toxicology studies completed.
2012
CF Trust withdraws funding from the Consortium (limited funding provided to March 2012).
Consortium awarded grants from the MRC & NIHR to continue clinical trial and research programmes.
Start of multi-dose Clinical trial to assess efficacy of GL67/pGM169 formulation.
Rosie Barnes launches Just Gene Therapy to raise funds for the Consortium.
2014 - Proposed
End of multi-dose Clinical trial towards the middle of 2013.
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Cystic Fibrosis
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Medical Futures Innovation Award 2011